Guyton and Hall Textbook of Medical Physiology (Guyton Physiology) 14th Edition

Guyton and Hall Textbook of Medical Physiology, Fourteenth Edition by John E. Hall, PhD and Michael E. Hall, MD, MSc — Published by Elsevier

A 2026 Doody's Core Title selected as an Essential Purchase in Physiology and a TAA McGuffey Longevity Award winner, this is the world's foremost medical physiology textbook — a favorite of students and clinicians worldwide for more than six decades.

Known for its clear presentation style, single-author voice, and focus on content most relevant to clinical and pre-clinical students, this edition employs a distinctive format to ensure maximum learning and retention of complex concepts. A larger font size emphasizes core information, while supporting information, including clinical examples, are detailed in smaller font and highlighted in pale blue — making it easy to quickly skim the essential text or pursue more in-depth study.

The text contains more than 1,200 full-color drawings and diagrams, carefully crafted to make physiology easier to understand, and features expanded clinical coverage including obesity, metabolic and cardiovascular disorders, Alzheimer's disease, and other degenerative conditions. The book offers a clinically oriented perspective that bridges basic physiology with pathophysiology throughout, focusing on how the body maintains homeostasis to remain healthy and emphasizing principles that will aid in later clinical decision-making.

John E. Hall is the Arthur C. Guyton Professor and Chair of the Department of Physiology and Biophysics, and Director of the Mississippi Center for Obesity Research at the University of Mississippi Medical Center, where he worked alongside Dr. Guyton for nearly 30 years before assuming sole authorship. Michael E. Hall is Chair and Professor in the Department of Medicine and Department of Physiology and Biophysics at the University of Mississippi Medical Center, bringing cardiovascular medicine expertise to this landmark fourteenth edition.